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cb 5339  (MedChemExpress)


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    MedChemExpress cb 5339
    Cb 5339, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cb 5339/product/MedChemExpress
    Average 94 stars, based on 2 article reviews
    cb 5339 - by Bioz Stars, 2026-06
    94/100 stars

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    Clinical trial schema for the comparative study of <t>CB-5339</t> in tumor-bearing pet dogs. 2-week (Panel A) and 3-week dosing schedules (Panel B) were utilized in this clinical trial. PE = physical examination; BMA = bone marrow aspiration cytology; PBMCs = peripheral blood mononuclear cells; CBC = complete blood count; chem = serum biochemical panel; UA = urinalysis; PK = pharmacokinetic assessment; PO = per os/oral dosing.
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    Clinical trial schema for the comparative study of CB-5339 in tumor-bearing pet dogs. 2-week (Panel A) and 3-week dosing schedules (Panel B) were utilized in this clinical trial. PE = physical examination; BMA = bone marrow aspiration cytology; PBMCs = peripheral blood mononuclear cells; CBC = complete blood count; chem = serum biochemical panel; UA = urinalysis; PK = pharmacokinetic assessment; PO = per os/oral dosing.

    Journal: Molecular cancer therapeutics

    Article Title: Comparative oncology assessment of a novel inhibitor of valosin-containing protein in tumor-bearing dogs

    doi: 10.1158/1535-7163.MCT-22-0167

    Figure Lengend Snippet: Clinical trial schema for the comparative study of CB-5339 in tumor-bearing pet dogs. 2-week (Panel A) and 3-week dosing schedules (Panel B) were utilized in this clinical trial. PE = physical examination; BMA = bone marrow aspiration cytology; PBMCs = peripheral blood mononuclear cells; CBC = complete blood count; chem = serum biochemical panel; UA = urinalysis; PK = pharmacokinetic assessment; PO = per os/oral dosing.

    Article Snippet: An HPLC/MS/MS method was developed at Alturas Analytics, Inc. to determine concentrations of CB-5339 in dog K 2 EDTA plasma in accordance with internal Standardized Operating Procedures.

    Techniques:

    Comparisons of pharmacokinetic exposures obtained from n = 12 canine cancer patients receiving the Powder in Capsule formulation of CB-5339.

    Journal: Molecular cancer therapeutics

    Article Title: Comparative oncology assessment of a novel inhibitor of valosin-containing protein in tumor-bearing dogs

    doi: 10.1158/1535-7163.MCT-22-0167

    Figure Lengend Snippet: Comparisons of pharmacokinetic exposures obtained from n = 12 canine cancer patients receiving the Powder in Capsule formulation of CB-5339.

    Article Snippet: An HPLC/MS/MS method was developed at Alturas Analytics, Inc. to determine concentrations of CB-5339 in dog K 2 EDTA plasma in accordance with internal Standardized Operating Procedures.

    Techniques: Formulation

    Comparisons of pharmacokinetic exposures obtained from n = 12 canine cancer patients receiving the human clinical formulation of CB-5339.

    Journal: Molecular cancer therapeutics

    Article Title: Comparative oncology assessment of a novel inhibitor of valosin-containing protein in tumor-bearing dogs

    doi: 10.1158/1535-7163.MCT-22-0167

    Figure Lengend Snippet: Comparisons of pharmacokinetic exposures obtained from n = 12 canine cancer patients receiving the human clinical formulation of CB-5339.

    Article Snippet: An HPLC/MS/MS method was developed at Alturas Analytics, Inc. to determine concentrations of CB-5339 in dog K 2 EDTA plasma in accordance with internal Standardized Operating Procedures.

    Techniques: Formulation

    Comparison of timecourse samples representative of induction of pharmacodynamic markers K48 linkage-specific ubiquitin (A) and CHOP (B, by mRNA) in serial biopsy samples taken from 6 dogs receiving the human clinical formulation of CB-5339.

    Journal: Molecular cancer therapeutics

    Article Title: Comparative oncology assessment of a novel inhibitor of valosin-containing protein in tumor-bearing dogs

    doi: 10.1158/1535-7163.MCT-22-0167

    Figure Lengend Snippet: Comparison of timecourse samples representative of induction of pharmacodynamic markers K48 linkage-specific ubiquitin (A) and CHOP (B, by mRNA) in serial biopsy samples taken from 6 dogs receiving the human clinical formulation of CB-5339.

    Article Snippet: An HPLC/MS/MS method was developed at Alturas Analytics, Inc. to determine concentrations of CB-5339 in dog K 2 EDTA plasma in accordance with internal Standardized Operating Procedures.

    Techniques: Comparison, Formulation